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Tumor-derived PTHrP Triggers Adipose Tissue Browning and Cancer Cachexia

SUMMARY: Cachexia is a wasting disorder of adipose and skeletal muscle tissues that leads to profound weight loss and frailty. About half of all cancer patients suffer from cachexia, which impairs quality of life, limits cancer therapy and decreases survival. One key characteristic of cachexia is el...

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Bibliografske podrobnosti
izdano v:Nature
Main Authors: Kir, Serkan, White, James P., Kleiner, Sandra, Kazak, Lawrence, Cohen, Paul, Baracos, Vickie E., Spiegelman, Bruce M.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224962/
https://ncbi.nlm.nih.gov/pubmed/25043053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13528
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