Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity

Oxidation of cysteine thiols by physiological reactive oxygen species (ROS) initiates thermogenesis in brown and beige adipose tissues. Cellular selenocysteines, where sulfur is replaced with selenium, exhibit enhanced reactivity with ROS. Despite their critical roles in physiology, methods for broa...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Jedrychowski, Mark P., Lu, Gina Z., Szpyt, John, Mariotti, Marco, Garrity, Ryan, Paulo, Joao A., Schweppe, Devin K., Laznik-Bogoslavski, Dina, Kazak, Lawrence, Murphy, Michael P., Gladyshev, Vadim N., Gygi, Steven P., Chouchani, Edward T., Spiegelman, Bruce M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7245117/
https://ncbi.nlm.nih.gov/pubmed/32358195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001387117
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky