A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

Thermogenic brown and beige adipose tissues dissipate chemical energy as heat, and their thermogenic activities can combat obesity and diabetes. Herein the functional adaptations to cold of brown and beige adipose depots are examined using quantitative mitochondrial proteomics. We identify arginine/...

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Udgivet i:Cell
Main Authors: Kazak, Lawrence, Chouchani, Edward T., Jedrychowski, Mark P., Erickson, Brian K., Shinoda, Kosaku, Cohen, Paul, Vetrivelan, Ramalingam, Lu, Gina Z., Laznik-Bogoslavski, Dina, Hasenfuss, Sebastian C., Kajimura, Shingo, Gygi, Steve P., Spiegelman, Bruce M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656041/
https://ncbi.nlm.nih.gov/pubmed/26496606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.09.035
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