Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?

le Correia-Melo, Clara, Hewitt, Graeme, Passos, João F
Foilsithe 2014

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

le Hewitt, Graeme, Jurk, Diana, Marques, Francisco D.M., Correia-Melo, Clara, Hardy, Timothy, Gackowska, Agata, Anderson, Rhys, Taschuk, Morgan, Mann, Jelena, Passos, João F.
Foilsithe 2012

RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions

le Kotsantis, Panagiotis, Segura-Bayona, Sandra, Margalef, Pol, Marzec, Paulina, Ruis, Phil, Hewitt, Graeme, Bellelli, Roberto, Patel, Harshil, Goldstone, Robert, Poetsch, Anna R., Boulton, Simon J.
Foilsithe in Cell Rep (2020)

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN

le Stingele, Julian, Bellelli, Roberto, Alte, Ferdinand, Hewitt, Graeme, Sarek, Grzegorz, Maslen, Sarah L., Tsutakawa, Susan E., Borg, Annabel, Kjær, Svend, Tainer, John A., Skehel, J. Mark, Groll, Michael, Boulton, Simon J.
Foilsithe in Mol Cell (2016)

Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch

le Lehmann, Laura C., Bacic, Luka, Hewitt, Graeme, Brackmann, Klaus, Sabantsev, Anton, Gaullier, Guillaume, Pytharopoulou, Sofia, Degliesposti, Gianluca, Okkenhaug, Hanneke, Tan, Song, Costa, Alessandro, Skehel, J. Mark, Boulton, Simon J., Deindl, Sebastian
Foilsithe in Cell Rep (2020)

Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1

le Lehmann, Laura C., Hewitt, Graeme, Aibara, Shintaro, Leitner, Alexander, Marklund, Emil, Maslen, Sarah L., Maturi, Varun, Chen, Yang, van der Spoel, David, Skehel, J. Mark, Moustakas, Aristidis, Boulton, Simon J., Deindl, Sebastian
Foilsithe in Mol Cell (2017)

Lysosome-mediated processing of chromatin in senescence

le Ivanov, Andre, Pawlikowski, Jeff, Manoharan, Indrani, van Tuyn, John, Nelson, David M., Rai, Taranjit Singh, Shah, Parisha P., Hewitt, Graeme, Korolchuk, Viktor I., Passos, Joao F., Wu, Hong, Berger, Shelley L., Adams, Peter D.
Foilsithe 2013

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors

le Fugger, Kasper, Bajrami, Ilirjana, Silva Dos Santos, Mariana, Young, Sarah Jane, Kunzelmann, Simone, Kelly, Geoff, Hewitt, Graeme, Patel, Harshil, Goldstone, Robert, Carell, Thomas, Boulton, Simon J., MacRae, James, Taylor, Ian A., West, Stephen C.
Foilsithe in Science (2021)

SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance

le Panier, Stephanie, Maric, Marija, Hewitt, Graeme, Mason-Osann, Emily, Gali, Himabindu, Dai, Anqi, Labadorf, Adam, Guervilly, Jean-Hugues, Ruis, Philip, Segura-Bayona, Sandra, Belan, Ondrej, Marzec, Paulina, Gaillard, Pierre-Henri L., Flynn, Rachel L., Boulton, Simon J.
Foilsithe in Mol Cell (2019)

mTORC1 activity is supported by spatial association with focal adhesions

le Rabanal-Ruiz, Yoana, Byron, Adam, Wirth, Alexander, Madsen, Ralitsa, Sedlackova, Lucia, Hewitt, Graeme, Nelson, Glyn, Stingele, Julian, Wills, Jimi C., Zhang, Tong, Zeug, André, Fässler, Reinhard, Vanhaesebroeck, Bart, Maddocks, Oliver D.K., Ponimaskin, Evgeni, Carroll, Bernadette, Korolchuk, Viktor I.
Foilsithe in J Cell Biol (2021)

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease

le Birch, Jodie, Anderson, Rhys K., Correia-Melo, Clara, Jurk, Diana, Hewitt, Graeme, Marques, Francisco Madeira, Green, Nicola J., Moisey, Elizabeth, Birrell, Mark A., Belvisi, Maria G., Black, Fiona, Taylor, John J., Fisher, Andrew J., De Soyza, Anthony, Passos, João F.
Foilsithe in Am J Physiol Lung Cell Mol Physiol (2015)

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair

le Hewitt, Graeme, Carroll, Bernadette, Sarallah, Rezazadeh, Correia-Melo, Clara, Ogrodnik, Mikołaj, Nelson, Glyn, Otten, Elsje G., Manni, Diego, Antrobus, Robin, Morgan, Brian A., von Zglinicki, Thomas, Jurk, Diana, Seluanov, Andrei, Gorbunova, Vera, Johansen, Terje, Passos, João F., Korolchuk, Viktor I.
Foilsithe in Autophagy (2016)

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

le Jurk, Diana, Wilson, Caroline, Passos, João F., Oakley, Fiona, Correia-Melo, Clara, Greaves, Laura, Saretzki, Gabriele, Fox, Chris, Lawless, Conor, Anderson, Rhys, Hewitt, Graeme, Pender, Sylvia LF, Fullard, Nicola, Nelson, Glyn, Mann, Jelena, van de Sluis, Bart, Mann, Derek A., von Zglinicki, Thomas
Foilsithe 2014

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

le Hewitt, Graeme, Borel, Valerie, Segura-Bayona, Sandra, Takaki, Tohru, Ruis, Phil, Bellelli, Roberto, Lehmann, Laura C., Sommerova, Lucia, Vancevska, Aleksandra, Tomas-Loba, Antonia, Zhu, Kang, Cooper, Christopher, Fugger, Kasper, Patel, Harshil, Goldstone, Robert, Schneider-Luftman, Deborah, Herbert, Ellie, Stamp, Gordon, Brough, Rachel, Pettitt, Stephen, Lord, Christopher J., West, Stephen C., Ahel, Ivan, Ahel, Dragana, Chapman, J. Ross, Deindl, Sebastian, Boulton, Simon J.
Foilsithe in Mol Cell (2021)

Mitochondria are required for pro‐ageing features of the senescent phenotype

le Correia‐Melo, Clara, Marques, Francisco DM, Anderson, Rhys, Hewitt, Graeme, Hewitt, Rachael, Cole, John, Carroll, Bernadette M, Miwa, Satomi, Birch, Jodie, Merz, Alina, Rushton, Michael D, Charles, Michelle, Jurk, Diana, Tait, Stephen WG, Czapiewski, Rafal, Greaves, Laura, Nelson, Glyn, Bohlooly‐Y, Mohammad, Rodriguez‐Cuenca, Sergio, Vidal‐Puig, Antonio, Mann, Derek, Saretzki, Gabriele, Quarato, Giovanni, Green, Douglas R, Adams, Peter D, von Zglinicki, Thomas, Korolchuk, Viktor I, Passos, João F
Foilsithe in EMBO J (2016)

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

le Zatreanu, Diana, Robinson, Helen M. R., Alkhatib, Omar, Boursier, Marie, Finch, Harry, Geo, Lerin, Grande, Diego, Grinkevich, Vera, Heald, Robert A., Langdon, Sophie, Majithiya, Jayesh, McWhirter, Claire, Martin, Niall M. B., Moore, Shaun, Neves, Joana, Rajendra, Eeson, Ranzani, Marco, Schaedler, Theresia, Stockley, Martin, Wiggins, Kimberley, Brough, Rachel, Sridhar, Sandhya, Gulati, Aditi, Shao, Nan, Badder, Luned M., Novo, Daniela, Knight, Eleanor G., Marlow, Rebecca, Haider, Syed, Callen, Elsa, Hewitt, Graeme, Schimmel, Joost, Prevo, Remko, Alli, Christina, Ferdinand, Amanda, Bell, Cameron, Blencowe, Peter, Bot, Chris, Calder, Mathew, Charles, Mark, Curry, Jayne, Ekwuru, Tennyson, Ewings, Katherine, Krajewski, Wojciech, MacDonald, Ellen, McCarron, Hollie, Pang, Leon, Pedder, Chris, Rigoreau, Laurent, Swarbrick, Martin, Wheatley, Ed, Willis, Simon, Wong, Ai Ching, Nussenzweig, Andre, Tijsterman, Marcel, Tutt, Andrew, Boulton, Simon J., Higgins, Geoff S., Pettitt, Stephen J., Smith, Graeme C. M., Lord, Christopher J.
Foilsithe in Nat Commun (2021)