Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1

Human ALC1 is an oncogene-encoded chromatin-remodeling enzyme required for DNA repair that possesses a poly(ADP-ribose) (PAR)-binding macro domain. Its engagement with PARylated PARP1 activates ALC1 at sites of DNA damage, but the underlying mechanism remains unclear. Here, we establish a dual role...

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Publié dans:Mol Cell
Auteurs principaux: Lehmann, Laura C., Hewitt, Graeme, Aibara, Shintaro, Leitner, Alexander, Marklund, Emil, Maslen, Sarah L., Maturi, Varun, Chen, Yang, van der Spoel, David, Skehel, J. Mark, Moustakas, Aristidis, Boulton, Simon J., Deindl, Sebastian
Format: Artigo
Langue:Inglês
Publié: Cell Press 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745148/
https://ncbi.nlm.nih.gov/pubmed/29220652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.10.017
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