Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1

Human ALC1 is an oncogene-encoded chromatin-remodeling enzyme required for DNA repair that possesses a poly(ADP-ribose) (PAR)-binding macro domain. Its engagement with PARylated PARP1 activates ALC1 at sites of DNA damage, but the underlying mechanism remains unclear. Here, we establish a dual role...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell
Asıl Yazarlar: Lehmann, Laura C., Hewitt, Graeme, Aibara, Shintaro, Leitner, Alexander, Marklund, Emil, Maslen, Sarah L., Maturi, Varun, Chen, Yang, van der Spoel, David, Skehel, J. Mark, Moustakas, Aristidis, Boulton, Simon J., Deindl, Sebastian
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cell Press 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745148/
https://ncbi.nlm.nih.gov/pubmed/29220652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.10.017
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