Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?

Por Correia-Melo, Clara, Hewitt, Graeme, Passos, João F
Publicado em 2014

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

Por Hewitt, Graeme, Jurk, Diana, Marques, Francisco D.M., Correia-Melo, Clara, Hardy, Timothy, Gackowska, Agata, Anderson, Rhys, Taschuk, Morgan, Mann, Jelena, Passos, João F.
Publicado em 2012

RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions

Por Kotsantis, Panagiotis, Segura-Bayona, Sandra, Margalef, Pol, Marzec, Paulina, Ruis, Phil, Hewitt, Graeme, Bellelli, Roberto, Patel, Harshil, Goldstone, Robert, Poetsch, Anna R., Boulton, Simon J.
Publicado no Cell Rep (2020)

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN

Por Stingele, Julian, Bellelli, Roberto, Alte, Ferdinand, Hewitt, Graeme, Sarek, Grzegorz, Maslen, Sarah L., Tsutakawa, Susan E., Borg, Annabel, Kjær, Svend, Tainer, John A., Skehel, J. Mark, Groll, Michael, Boulton, Simon J.
Publicado no Mol Cell (2016)

Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch

Por Lehmann, Laura C., Bacic, Luka, Hewitt, Graeme, Brackmann, Klaus, Sabantsev, Anton, Gaullier, Guillaume, Pytharopoulou, Sofia, Degliesposti, Gianluca, Okkenhaug, Hanneke, Tan, Song, Costa, Alessandro, Skehel, J. Mark, Boulton, Simon J., Deindl, Sebastian
Publicado no Cell Rep (2020)

Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1

Por Lehmann, Laura C., Hewitt, Graeme, Aibara, Shintaro, Leitner, Alexander, Marklund, Emil, Maslen, Sarah L., Maturi, Varun, Chen, Yang, van der Spoel, David, Skehel, J. Mark, Moustakas, Aristidis, Boulton, Simon J., Deindl, Sebastian
Publicado no Mol Cell (2017)

Lysosome-mediated processing of chromatin in senescence

Por Ivanov, Andre, Pawlikowski, Jeff, Manoharan, Indrani, van Tuyn, John, Nelson, David M., Rai, Taranjit Singh, Shah, Parisha P., Hewitt, Graeme, Korolchuk, Viktor I., Passos, Joao F., Wu, Hong, Berger, Shelley L., Adams, Peter D.
Publicado em 2013

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors

Por Fugger, Kasper, Bajrami, Ilirjana, Silva Dos Santos, Mariana, Young, Sarah Jane, Kunzelmann, Simone, Kelly, Geoff, Hewitt, Graeme, Patel, Harshil, Goldstone, Robert, Carell, Thomas, Boulton, Simon J., MacRae, James, Taylor, Ian A., West, Stephen C.
Publicado no Science (2021)

SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance

Por Panier, Stephanie, Maric, Marija, Hewitt, Graeme, Mason-Osann, Emily, Gali, Himabindu, Dai, Anqi, Labadorf, Adam, Guervilly, Jean-Hugues, Ruis, Philip, Segura-Bayona, Sandra, Belan, Ondrej, Marzec, Paulina, Gaillard, Pierre-Henri L., Flynn, Rachel L., Boulton, Simon J.
Publicado no Mol Cell (2019)

mTORC1 activity is supported by spatial association with focal adhesions

Por Rabanal-Ruiz, Yoana, Byron, Adam, Wirth, Alexander, Madsen, Ralitsa, Sedlackova, Lucia, Hewitt, Graeme, Nelson, Glyn, Stingele, Julian, Wills, Jimi C., Zhang, Tong, Zeug, André, Fässler, Reinhard, Vanhaesebroeck, Bart, Maddocks, Oliver D.K., Ponimaskin, Evgeni, Carroll, Bernadette, Korolchuk, Viktor I.
Publicado no J Cell Biol (2021)

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease

Por Birch, Jodie, Anderson, Rhys K., Correia-Melo, Clara, Jurk, Diana, Hewitt, Graeme, Marques, Francisco Madeira, Green, Nicola J., Moisey, Elizabeth, Birrell, Mark A., Belvisi, Maria G., Black, Fiona, Taylor, John J., Fisher, Andrew J., De Soyza, Anthony, Passos, João F.
Publicado no Am J Physiol Lung Cell Mol Physiol (2015)

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair

Por Hewitt, Graeme, Carroll, Bernadette, Sarallah, Rezazadeh, Correia-Melo, Clara, Ogrodnik, Mikołaj, Nelson, Glyn, Otten, Elsje G., Manni, Diego, Antrobus, Robin, Morgan, Brian A., von Zglinicki, Thomas, Jurk, Diana, Seluanov, Andrei, Gorbunova, Vera, Johansen, Terje, Passos, João F., Korolchuk, Viktor I.
Publicado no Autophagy (2016)

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

Por Jurk, Diana, Wilson, Caroline, Passos, João F., Oakley, Fiona, Correia-Melo, Clara, Greaves, Laura, Saretzki, Gabriele, Fox, Chris, Lawless, Conor, Anderson, Rhys, Hewitt, Graeme, Pender, Sylvia LF, Fullard, Nicola, Nelson, Glyn, Mann, Jelena, van de Sluis, Bart, Mann, Derek A., von Zglinicki, Thomas
Publicado em 2014

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

Por Hewitt, Graeme, Borel, Valerie, Segura-Bayona, Sandra, Takaki, Tohru, Ruis, Phil, Bellelli, Roberto, Lehmann, Laura C., Sommerova, Lucia, Vancevska, Aleksandra, Tomas-Loba, Antonia, Zhu, Kang, Cooper, Christopher, Fugger, Kasper, Patel, Harshil, Goldstone, Robert, Schneider-Luftman, Deborah, Herbert, Ellie, Stamp, Gordon, Brough, Rachel, Pettitt, Stephen, Lord, Christopher J., West, Stephen C., Ahel, Ivan, Ahel, Dragana, Chapman, J. Ross, Deindl, Sebastian, Boulton, Simon J.
Publicado no Mol Cell (2021)

Mitochondria are required for pro‐ageing features of the senescent phenotype

Por Correia‐Melo, Clara, Marques, Francisco DM, Anderson, Rhys, Hewitt, Graeme, Hewitt, Rachael, Cole, John, Carroll, Bernadette M, Miwa, Satomi, Birch, Jodie, Merz, Alina, Rushton, Michael D, Charles, Michelle, Jurk, Diana, Tait, Stephen WG, Czapiewski, Rafal, Greaves, Laura, Nelson, Glyn, Bohlooly‐Y, Mohammad, Rodriguez‐Cuenca, Sergio, Vidal‐Puig, Antonio, Mann, Derek, Saretzki, Gabriele, Quarato, Giovanni, Green, Douglas R, Adams, Peter D, von Zglinicki, Thomas, Korolchuk, Viktor I, Passos, João F
Publicado no EMBO J (2016)