Mitochondria are required for pro‐ageing features of the senescent phenotype

Cell senescence is an important tumour suppressor mechanism and driver of ageing. Both functions are dependent on the development of the senescent phenotype, which involves an overproduction of pro‐inflammatory and pro‐oxidant signals. However, the exact mechanisms regulating these phenotypes remain...

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Publicado en:EMBO J
Main Authors: Correia‐Melo, Clara, Marques, Francisco DM, Anderson, Rhys, Hewitt, Graeme, Hewitt, Rachael, Cole, John, Carroll, Bernadette M, Miwa, Satomi, Birch, Jodie, Merz, Alina, Rushton, Michael D, Charles, Michelle, Jurk, Diana, Tait, Stephen WG, Czapiewski, Rafal, Greaves, Laura, Nelson, Glyn, Bohlooly‐Y, Mohammad, Rodriguez‐Cuenca, Sergio, Vidal‐Puig, Antonio, Mann, Derek, Saretzki, Gabriele, Quarato, Giovanni, Green, Douglas R, Adams, Peter D, von Zglinicki, Thomas, Korolchuk, Viktor I, Passos, João F
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818766/
https://ncbi.nlm.nih.gov/pubmed/26848154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201592862
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