Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria

Telomerase in its canonical function maintains telomeres in dividing cells. In addition, the telomerase protein TERT has non-telomeric functions such as shuttling to mitochondria resulting in a decreased oxidative stress, DNA damage and apoptosis. TERT protein persists in adult neurons and can co-lo...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Miwa, Satomi, Czapiewski, Rafal, Wan, Tengfei, Bell, Amy, Hill, Kirsten N., von Zglinicki, Thomas, Saretzki, Gabriele
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115906/
https://ncbi.nlm.nih.gov/pubmed/27777385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101089
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