Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria

Telomerase in its canonical function maintains telomeres in dividing cells. In addition, the telomerase protein TERT has non-telomeric functions such as shuttling to mitochondria resulting in a decreased oxidative stress, DNA damage and apoptosis. TERT protein persists in adult neurons and can co-lo...

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Bibliografiske detaljer
Udgivet i:Aging (Albany NY)
Main Authors: Miwa, Satomi, Czapiewski, Rafal, Wan, Tengfei, Bell, Amy, Hill, Kirsten N., von Zglinicki, Thomas, Saretzki, Gabriele
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115906/
https://ncbi.nlm.nih.gov/pubmed/27777385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101089
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