Human stem cell aging: do mitochondrial DNA mutations have a causal role?

Por Baines, Holly L, Turnbull, Douglass M, Greaves, Laura C
Publicado no Aging Cell (2014)

The ageing mitochondrial genome

Por Krishnan, Kim J., Greaves, Laura C., Reeve, Amy K., Turnbull, Doug
Publicado em 2007

Modelling mitochondrial DNA mutations in bacterial cytochrome c oxidase: Link to colon cancer?

Por Greaves, Laura C., Mathers, John C., Taylor, Robert W., Turnbull, Douglass M.
Publicado em 2009

Quantification of mitochondrial DNA mutation load

Por Greaves, Laura C, Beadle, Nina E, Taylor, Geoffrey A, Commane, Daniel, Mathers, John C, Khrapko, Konstantin, Turnbull, Doug M
Publicado em 2009

Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts

Por Greaves, Laura C., Barron, Martin J., Plusa, Stefan, Kirkwood, Thomas B., Mathers, John C., Taylor, Robert W., Turnbull, Doug M.
Publicado em 2010

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

Por Baines, Holly L., Stewart, James B., Stamp, Craig, Zupanic, Anze, Kirkwood, Thomas B.L., Larsson, Nils-Göran, Turnbull, Douglass M., Greaves, Laura C.
Publicado em 2014

The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease

Por Elson, Joanna L., Smith, Paul M., Greaves, Laura C., Lightowlers, Robert N., Chrzanowska-Lightowlers, Zofia M.A., Taylor, Robert W., Vila-Sanjurjo, Antón
Publicado no Mitochondrion (2015)

Unique quadruple immunofluorescence assay demonstrates mitochondrial respiratory chain dysfunction in osteoblasts of aged and PolgA(−/−) mice

Por Dobson, Philip F., Rocha, Mariana C., Grady, John P., Chrysostomou, Alexia, Hipps, Daniel, Watson, Sharon, Greaves, Laura C., Deehan, David J., Turnbull, Doug M.
Publicado no Sci Rep (2016)

Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts

Por Nooteboom, Marco, Johnson, Riem, Taylor, Robert W, Wright, Nicholas A, Lightowlers, Robert N, Kirkwood, Thomas B L, Mathers, John C, Turnbull, Doug M, Greaves, Laura C
Publicado em 2010

Somatic Mitochondrial DNA Deletions Accumulate to High Levels in Aging Human Extraocular Muscles

Por Yu-Wai-Man, Patrick, Lai-Cheong, Joey, Borthwick, Gillian M., He, Langping, Taylor, Geoffrey A., Greaves, Laura C., Taylor, Robert W., Griffiths, Philip G., Turnbull, Douglass M.
Publicado em 2010

Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutation...

Por Greaves, Laura C., Elson, Joanna L., Nooteboom, Marco, Grady, John P., Taylor, Geoffrey A., Taylor, Robert W., Mathers, John C., Kirkwood, Thomas B. L., Turnbull, Doug M.
Publicado em 2012

The role of the mitochondrial ribosome in human disease: searching for mutations in 12S mitochondrial rRNA with high disruptive potential

Por Smith, Paul M., Elson, Joanna L., Greaves, Laura C., Wortmann, Saskia B., Rodenburg, Richard J.T., Lightowlers, Robert N., Chrzanowska-Lightowlers, Zofia M.A., Taylor, Robert W., Vila-Sanjurjo, Antón
Publicado em 2014

A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease

Por Kauppila, Johanna H.K., Baines, Holly L., Bratic, Ana, Simard, Marie-Lune, Freyer, Christoph, Mourier, Arnaud, Stamp, Craig, Filograna, Roberta, Larsson, Nils-Göran, Greaves, Laura C., Stewart, James B.
Publicado no Cell Rep (2016)

Mitochondrial DNA Defects and Selective Extraocular Muscle Involvement in CPEO

Por Greaves, Laura C., Yu-Wai-Man, Patrick, Blakely, Emma L., Krishnan, Kim J., Beadle, Nina E., Kerin, Jamie, Barron, Martin J., Griffiths, Philip G., Dickinson, Alison J., Turnbull, Douglass M., Taylor, Robert W.
Publicado em 2010

Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy

Por Di Foggia, Valentina, Zhang, Xinyu, Licastro, Danilo, Gerli, Mattia F.M., Phadke, Rahul, Muntoni, Francesco, Mourikis, Philippos, Tajbakhsh, Shahragim, Ellis, Matthew, Greaves, Laura C., Taylor, Robert W., Cossu, Giulio, Robson, Lesley G., Marino, Silvia
Publicado no J Exp Med (2014)

Mitochondrial DNA mutations in human colonic crypt stem cells

Por Taylor, Robert W., Barron, Martin J., Borthwick, Gillian M., Gospel, Amy, Chinnery, Patrick F., Samuels, David C., Taylor, Geoffrey A., Plusa, Stefan M., Needham, Stephanie J., Greaves, Laura C., Kirkwood, Thomas B.L., Turnbull, Douglass M.
Publicado em 2003

Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing

Por Greaves, Laura C., Nooteboom, Marco, Elson, Joanna L., Tuppen, Helen A. L., Taylor, Geoffrey A., Commane, Daniel M., Arasaradnam, Ramesh P., Khrapko, Konstantin, Taylor, Robert W., Kirkwood, Thomas B. L., Mathers, John C., Turnbull, Douglass M.
Publicado em 2014

Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates

Por Moad, Mohammad, Hannezo, Edouard, Buczacki, Simon J., Wilson, Laura, El-Sherif, Amira, Sims, David, Pickard, Robert, Wright, Nicholas A., Williamson, Stuart C., Turnbull, Doug M., Taylor, Robert W., Greaves, Laura, Robson, Craig N., Simons, Benjamin D., Heer, Rakesh
Publicado no Cell Rep (2017)

Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression

Por Gorman, Grainne S., Blakely, Emma L., Hornig-Do, Hue-Tran, Tuppen, Helen A.L., Greaves, Laura C., He, Langping, Baker, Angela, Falkous, Gavin, Newman, Jane, Trenell, Michael I., Lecky, Bryan, Petty, Richard K., Turnbull, Doug M., McFarland, Robert, Taylor, Robert W.
Publicado no Clin Sci (Lond) (2015)

Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission

Por Greaves, Laura C., Preston, Sean L., Tadrous, Paul J., Taylor, Robert W., Barron, Martin J., Oukrif, Dahmane, Leedham, Simon J., Deheragoda, Maesha, Sasieni, Peter, Novelli, Marco R., Jankowski, Janusz A. Z., Turnbull, Douglass M., Wright, Nicholas A., McDonald, Stuart A. C.
Publicado em 2006