Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts

Mitochondrial DNA (mtDNA) mutations are a cause of human disease and are proposed to have a role in human aging. Clonally expanded mtDNA point mutations have been detected in replicating tissues and have been shown to cause respiratory chain (RC) defects. The effect of these mutations on other cellu...

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Detalhes bibliográficos
Main Authors: Nooteboom, Marco, Johnson, Riem, Taylor, Robert W, Wright, Nicholas A, Lightowlers, Robert N, Kirkwood, Thomas B L, Mathers, John C, Turnbull, Doug M, Greaves, Laura C
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
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Short Takes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816353/
https://ncbi.nlm.nih.gov/pubmed/19878146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2009.00531.x
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