Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations

Human ageing has been predicted to be caused by the accumulation of molecular damage in cells and tissues. Somatic mitochondrial DNA (mtDNA) mutations have been documented in a number of ageing tissues and have been shown to be associated with cellular mitochondrial dysfunction. It is unknown whethe...

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Main Authors: Greaves, Laura C., Elson, Joanna L., Nooteboom, Marco, Grady, John P., Taylor, Geoffrey A., Taylor, Robert W., Mathers, John C., Kirkwood, Thomas B. L., Turnbull, Doug M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499406/
https://ncbi.nlm.nih.gov/pubmed/23166522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003082
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