Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations

Human ageing has been predicted to be caused by the accumulation of molecular damage in cells and tissues. Somatic mitochondrial DNA (mtDNA) mutations have been documented in a number of ageing tissues and have been shown to be associated with cellular mitochondrial dysfunction. It is unknown whethe...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Greaves, Laura C., Elson, Joanna L., Nooteboom, Marco, Grady, John P., Taylor, Geoffrey A., Taylor, Robert W., Mathers, John C., Kirkwood, Thomas B. L., Turnbull, Doug M.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499406/
https://ncbi.nlm.nih.gov/pubmed/23166522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003082
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires