Quantification of mitochondrial DNA mutation load

Mitochondrial DNA (mtDNA) mutations are an important cause of genetic disease and have been proposed to play a role in the ageing process. Quantification of total mtDNA mutation load in ageing tissues is difficult as mutational events are rare in a background of wild-type molecules, and detection of...

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Detalhes bibliográficos
Main Authors: Greaves, Laura C, Beadle, Nina E, Taylor, Geoffrey A, Commane, Daniel, Mathers, John C, Khrapko, Konstantin, Turnbull, Doug M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752485/
https://ncbi.nlm.nih.gov/pubmed/19624578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2009.00505.x
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