Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.

Age-related decline in the integrity of mitochondria is an important contributor to the human ageing process. In a number of ageing stem cell populations, this decline in mitochondrial function is due to clonal expansion of individual mitochondrial DNA (mtDNA) point mutations within single cells. Ho...

Deskribapen osoa

Xehetasun bibliografikoak

Egile Nagusiak:	Laura C Greaves, Marco Nooteboom, Joanna L Elson, Helen A L Tuppen, Geoffrey A Taylor, Daniel M Commane, Ramesh P Arasaradnam, Konstantin Khrapko, Robert W Taylor, Thomas B L Kirkwood, John C Mathers, Douglass M Turnbull
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Public Library of Science (PLoS) 2014-09-01
Saila:	PLoS Genetics
Sarrera elektronikoa:	https://doi.org/10.1371/journal.pgen.1004620
Etiketak:	Etiketa erantsi Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!