Age‐associated mitochondrial complex I deficiency is linked to increased stem cell proliferation rates in the mouse colon

One of the hallmarks of aging is an accumulation of cells with defects in oxidative phosphorylation (OXPHOS) due to mutations of mitochondrial DNA (mtDNA). Rapidly dividing tissues maintained by stem cells, such as the colonic epithelium, are particularly susceptible to accumulation of OXPHOS defect...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Stamp, Craig, Whitehall, Julia C., Smith, Anna L. M., Houghton, David, Bradshaw, Carla, Stoll, Elizabeth A., Blain, Alasdair P., Turnbull, Doug M., Greaves, Laura C.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Short Take
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7963326/
https://ncbi.nlm.nih.gov/pubmed/33626245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13321
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