Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss

The pathogenesis of declining bone mineral density, a universal feature of ageing, is not fully understood. Somatic mitochondrial DNA (mtDNA) mutations accumulate with age in human tissues and mounting evidence suggests that they may be integral to the ageing process. To explore the potential effect...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Sci Rep
Autores principales: Dobson, Philip F., Dennis, Ella P., Hipps, Daniel, Reeve, Amy, Laude, Alex, Bradshaw, Carla, Stamp, Craig, Smith, Anna, Deehan, David J., Turnbull, Doug M., Greaves, Laura C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363892/
https://ncbi.nlm.nih.gov/pubmed/32669663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68566-2
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares