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Unique quadruple immunofluorescence assay demonstrates mitochondrial respiratory chain dysfunction in osteoblasts of aged and PolgA(−/−) mice

Fragility fractures caused by osteoporosis affect millions of people worldwide every year with significant levels of associated morbidity, mortality and costs to the healthcare economy. The pathogenesis of declining bone mineral density is poorly understood but it is inherently related to increasing...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dobson, Philip F., Rocha, Mariana C., Grady, John P., Chrysostomou, Alexia, Hipps, Daniel, Watson, Sharon, Greaves, Laura C., Deehan, David J., Turnbull, Doug M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995399/
https://ncbi.nlm.nih.gov/pubmed/27553587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31907
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