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Unique quadruple immunofluorescence assay demonstrates mitochondrial respiratory chain dysfunction in osteoblasts of aged and PolgA(−/−) mice

Fragility fractures caused by osteoporosis affect millions of people worldwide every year with significant levels of associated morbidity, mortality and costs to the healthcare economy. The pathogenesis of declining bone mineral density is poorly understood but it is inherently related to increasing...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Dobson, Philip F., Rocha, Mariana C., Grady, John P., Chrysostomou, Alexia, Hipps, Daniel, Watson, Sharon, Greaves, Laura C., Deehan, David J., Turnbull, Doug M.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995399/
https://ncbi.nlm.nih.gov/pubmed/27553587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31907
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