Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy

The Polycomb group (PcG) protein Bmi1 is an essential epigenetic regulator of stem cell function during normal development and in adult organ systems. We show that mild up-regulation of Bmi1 expression in the adult stem cells of the skeletal muscle leads to a remarkable improvement of muscle functio...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Di Foggia, Valentina, Zhang, Xinyu, Licastro, Danilo, Gerli, Mattia F.M., Phadke, Rahul, Muntoni, Francesco, Mourikis, Philippos, Tajbakhsh, Shahragim, Ellis, Matthew, Greaves, Laura C., Taylor, Robert W., Cossu, Giulio, Robson, Lesley G., Marino, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267246/
https://ncbi.nlm.nih.gov/pubmed/25452464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140317
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