Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission

The understanding of the fixation of mutations within human tissues and their subsequent clonal expansion is a considerable problem, of which little is known. We have previously shown that nononcogenic mutations in the mitochondrial genome occur in one of a number of morphologically normal colonic c...

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Hauptverfasser: Greaves, Laura C., Preston, Sean L., Tadrous, Paul J., Taylor, Robert W., Barron, Martin J., Oukrif, Dahmane, Leedham, Simon J., Deheragoda, Maesha, Sasieni, Peter, Novelli, Marco R., Jankowski, Janusz A. Z., Turnbull, Douglass M., Wright, Nicholas A., McDonald, Stuart A. C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1325106/
https://ncbi.nlm.nih.gov/pubmed/16407113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505903103
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