RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions

Regulator of telomere length 1 (RTEL1) is an essential helicase that maintains telomere integrity and facilitates DNA replication. The source of replication stress in Rtel1-deficient cells remains unclear. Here, we report that loss of RTEL1 confers extensive transcriptional changes independent of it...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Kotsantis, Panagiotis, Segura-Bayona, Sandra, Margalef, Pol, Marzec, Paulina, Ruis, Phil, Hewitt, Graeme, Bellelli, Roberto, Patel, Harshil, Goldstone, Robert, Poetsch, Anna R., Boulton, Simon J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773548/
https://ncbi.nlm.nih.gov/pubmed/33357438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108546
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