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Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN
Covalent DNA-protein crosslinks (DPCs) are toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription. Little was known about DPC-specific repair mechanisms until the recent identification of a DPC-processing protease in yeast. The existence of a DP...
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Pubblicato in: | Mol Cell |
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Autori principali: | , , , , , , , , , , , , |
Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
Cell Press
2016
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5128726/ https://ncbi.nlm.nih.gov/pubmed/27871365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.09.031 |
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