DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease

Repair of covalent DNA-protein crosslinks (DPCs) by DNA-dependent proteases has emerged as an essential genome maintenance mechanism required for cellular viability and tumor suppression. However, how proteolysis is restricted to the crosslinked protein while leaving surrounding chromatin proteins u...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Reinking, Hannah K., Kang, Hyun-Seo, Götz, Maximilian J., Li, Hao-Yi, Kieser, Anja, Zhao, Shubo, Acampora, Aleida C., Weickert, Pedro, Fessler, Evelyn, Jae, Lucas T., Sattler, Michael, Stingele, Julian
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534798/
https://ncbi.nlm.nih.gov/pubmed/32853547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.08.003
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