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Protein-oligonucleotide conjugates as model substrates for DNA-protein crosslink repair proteases

Covalent DNA-protein crosslinks (DPCs) have emerged as pervasive sources of genome instability. DPCs are targeted for repair by DNA-dependent proteases of the Wss1/SPRTN family. However, understanding how these enzymes achieve specificity has been hampered by the lack of suitable in vitro model subs...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:STAR Protoc
Hauptverfasser: Reinking, Hannah K., Stingele, Julian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8219891/
https://ncbi.nlm.nih.gov/pubmed/34189469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xpro.2021.100591
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