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A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN
Repair of covalent DNA–protein crosslinks (DPCs) by the metalloprotease SPRTN prevents genome instability, premature aging and carcinogenesis. SPRTN is specifically activated by DNA structures containing single- and double-stranded features, but degrades the protein components of DPCs promiscuously...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7826251/ https://ncbi.nlm.nih.gov/pubmed/33348378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1224 |
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