A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN

Repair of covalent DNA–protein crosslinks (DPCs) by the metalloprotease SPRTN prevents genome instability, premature aging and carcinogenesis. SPRTN is specifically activated by DNA structures containing single- and double-stranded features, but degrades the protein components of DPCs promiscuously...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Zhao, Shubo, Kieser, Anja, Li, Hao-Yi, Reinking, Hannah K, Weickert, Pedro, Euteneuer, Simon, Yaneva, Denitsa, Acampora, Aleida C, Götz, Maximilian J, Feederle, Regina, Stingele, Julian
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826251/
https://ncbi.nlm.nih.gov/pubmed/33348378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1224
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