SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks

Ruijs-Aalfs syndrome is a segmental progeroid syndrome resulting from mutations in the SPRTN gene. Cells derived from patients with SPRTN mutations elicit genomic instability and people afflicted with this syndrome developed hepatocellular carcinoma. Here we describe the molecular mechanism by which...

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Bibliographic Details
Published in:eLife
Main Authors: Lopez-Mosqueda, Jaime, Maddi, Karthik, Prgomet, Stefan, Kalayil, Sissy, Marinovic-Terzic, Ivana, Terzic, Janos, Dikic, Ivan
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2016
Subjects:
Biochemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127644/
https://ncbi.nlm.nih.gov/pubmed/27852435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21491
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