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SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks
Ruijs-Aalfs syndrome is a segmental progeroid syndrome resulting from mutations in the SPRTN gene. Cells derived from patients with SPRTN mutations elicit genomic instability and people afflicted with this syndrome developed hepatocellular carcinoma. Here we describe the molecular mechanism by which...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5127644/ https://ncbi.nlm.nih.gov/pubmed/27852435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21491 |
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