USP11 mediates repair of DNA–protein cross-links by deubiquitinating SPRTN metalloprotease

DNA–protein cross-links (DPCs) are toxic DNA lesions that interfere with DNA metabolic processes such as replication, transcription, and recombination. USP11 deubiquitinase participates in DNA repair, but the role of USP11 in DPC repair is not known. SPRTN is a replication-coupled DNA-dependent meta...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Perry, Megan, Biegert, Meghan, Kollala, Sai Sundeep, Mallard, Halle, Su, Grace, Kodavati, Manohar, Kreiling, Natasha, Holbrook, Alexander, Ghosal, Gargi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7960550/
https://ncbi.nlm.nih.gov/pubmed/33567341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100396
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