Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1

Human ALC1 is an oncogene-encoded chromatin-remodeling enzyme required for DNA repair that possesses a poly(ADP-ribose) (PAR)-binding macro domain. Its engagement with PARylated PARP1 activates ALC1 at sites of DNA damage, but the underlying mechanism remains unclear. Here, we establish a dual role...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Lehmann, Laura C., Hewitt, Graeme, Aibara, Shintaro, Leitner, Alexander, Marklund, Emil, Maslen, Sarah L., Maturi, Varun, Chen, Yang, van der Spoel, David, Skehel, J. Mark, Moustakas, Aristidis, Boulton, Simon J., Deindl, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745148/
https://ncbi.nlm.nih.gov/pubmed/29220652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.10.017
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