Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation

por Leslie, Kenneth, Gao, Sizhi P, Berishaj, Marjan, Podsypanina, Katrina, Ho, Hao, Ivashkiv, Lionel, Bromberg, Jacqueline
Publicado 2010

MET activation mediates resistance to lapatinib inhibition of HER2-amplified gastric cancer cells

por Chen, Chin-Tung, Kim, Hyaehwan, Liska, David, Gao, Sizhi, Christensen, James G., Weiser, Martin R.
Publicado 2012

A phase 1/2 trial of ruxolitinib and erlotinib in patients with EGFR-mutant lung adenocarcinomas with acquired resistance to erlotinib

por Yu, Helena A., Perez, Leslie, Chang, Qing, Gao, Sizhi P., Kris, Mark G., Riely, Gregory J., Bromberg, Jacqueline
Publicado en J Thorac Oncol (2016)

Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling

por Zhu, Fanfan, Dai, Chunyan, Fu, Yufei, Loo, Jacky F.C., Xia, Dajin, Gao, Sizhi P., Ma, Zhongjun, Chen, Zhe
Publicado en Oncotarget (2016)

Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer

por Berishaj, Marjan, Gao, Sizhi Paul, Ahmed, Simi, Leslie, Kenneth, Al-Ahmadie, Hikmat, Gerald, William L, Bornmann, William, Bromberg, Jacqueline F
Publicado 2007

Activating mutation of PDGFRB gene in a rare cardiac undifferentiated intimal sarcoma of the left atrium: a case report

por Fu, Xiaoling, Niu, Weixin, Li, Ji, Kiliti, Amber J., Al-Ahmadie, Hikmat A., Iyer, Gopa, Gao, Sizhi Paul, Li, Qi
Publicado en Oncotarget (2017)

Synergy of a Herpes OncolyticVirus and Paclitaxel for Anaplastic Thyroid Cancer

por Lin, Shu-Fu, Gao, Sizhi Paul, Price, Daniel L., Li, Sen, Chou, Ting-Chao, Singh, Paramjeet, Huang, Yu-Yao, Fong, Yuman, Wong, Richard J.
Publicado 2008

Paracrine Regulation of Pancreatic Cancer Cell Invasion by Peripheral Nerves

por Gil, Ziv, Cavel, Oren, Kelly, Kaitlyn, Brader, Peter, Rein, Avigail, Gao, Sizhi P., Carlson, Diane L., Shah, Jatin P., Fong, Yuman, Wong, Richard J.
Publicado 2010

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

por Gao, Sizhi Paul, Mark, Kevin G., Leslie, Kenneth, Pao, William, Motoi, Noriko, Gerald, William L., Travis, William D., Bornmann, William, Veach, Darren, Clarkson, Bayard, Bromberg, Jacqueline F.
Publicado 2007

3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets

por Gao, Jianjiong, Chang, Matthew T., Johnsen, Hannah C., Gao, Sizhi Paul, Sylvester, Brooke E., Sumer, Selcuk Onur, Zhang, Hongxin, Solit, David B., Taylor, Barry S., Schultz, Nikolaus, Sander, Chris
Publicado en Genome Med (2017)

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

por Chang, Matthew T., Asthana, Saurabh, Gao, Sizhi Paul, Lee, Byron H., Chapman, Jocelyn S., Kandoth, Cyriac, Gao, JianJiong, Socci, Nicholas D., Solit, David B., Olshen, Adam B., Schultz, Nikolaus, Taylor, Barry S.
Publicado en Nat Biotechnol (2015)

Bacillus as a potential diagnostic marker for yellow tongue coating

por Ye, Juan, Cai, Xueting, Yang, Jie, Sun, Xiaoyan, Hu, Chunping, Xia, Junquan, Shen, Jianping, Su, Kelei, Yan, Huaijiang, Xu, Yuehua, Zhang, Yiyan, Zhang, Sujie, Yang, Lijun, Zhi, Hao, Gao, Sizhi Paul, Yu, Qiang, Hu, Jingqing, Cao, Peng
Publicado en Sci Rep (2016)

AKT1 E17K inhibits cancer cell migration by abrogating β-catenin signaling

por Gao, Sizhi Paul, Kiliti, Amber J., Zhang, Kai, Vasani, Naresh, Mao, Ninghui, Jordan, Emmet, Wise, Hannah C., Bhattarai, Tripti Shrestha, Hu, Wenhuo, Dorso, Madeline, Rodrigues, James A., Kim, Kwanghee, Hanrahan, Aphrothiti J., Razavi, Pedram, Carver, Brett, Chandarlapaty, Sarat, Reis-Filho, Jorge S., Taylor, Barry S., Solit, David B.
Publicado en Mol Cancer Res (2020)

The IL-6/JAK/Stat3 Feed-Forward Loop Drives Tumorigenesis and Metastasis

por Chang, Qing, Bournazou, Eirini, Sansone, Pasquale, Berishaj, Marjan, Gao, Sizhi Paul, Daly, Laura, Wels, Jared, Theilen, Till, Granitto, Selena, Zhang, Xinmin, Cotari, Jesse, Alpaugh, Mary L, de Stanchina, Elisa, Manova, Katia, Li, Ming, Bonafe, Massimiliano, Ceccarelli, Claudio, Taffurelli, Mario, Santini, Donatella, Altan-Bonnet, Gregoire, Kaplan, Rosandra, Norton, Larry, Nishimoto, Norihiro, Huszar, Dennis, Lyden, David, Bromberg, Jacqueline
Publicado 2013

JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors

por Gao, Sizhi P., Chang, Qing, Mao, Ninghui, Daly, Laura A., Vogel, Robert, Chan, Tyler, Liu, Shu Hui, Bournazou, Eirini, Schori, Erez, Zhang, Haiying, Brewer, Monica Red, Pao, William, Morris, Luc, Ladanyi, Marc, Arcila, Maria, Manova-Todorova, Katia, de Stanchina, Elisa, Norton, Larry, Levine, Ross L., Altan-Bonnet, Gregoire, Solit, David, Zinda, Michael, Huszar, Dennis, Lyden, David, Bromberg, Jacqueline F.
Publicado en Sci Signal (2016)

Leveraging systematic functional analysis to benchmark an in silico framework distinguishes driver from passenger MEK mutants in cancer

por Hanrahan, Aphrothiti J., Sylvester, Brooke E., Chang, Matthew T., Elzein, Arijh, Gao, JianJiong, Han, Weiwei, Liu, Ye, Xu, Dong, Gao, Sizhi P., Gorelick, Alexander N., Jones, Alexis M., Kiliti, Amber J., Nissan, Moriah H., Nimura, Clare A., Poteshman, Abigail N., Yao, Zhan, Gao, Yijun, Hu, Wenhuo, Wise, Hannah C., Gavrila, Elena I., Shoushtari, Alexander N., Tiwari, Shakuntala, Viale, Agnes, Abdel-Wahab, Omar, Merghoub, Taha, Berger, Michael F., Rosen, Neal, Taylor, Barry S., Solit, David B.
Publicado en Cancer Res (2020)

Identification of a synthetic lethal relationship between nucleotide excision repair (NER) deficiency and irofulven sensitivity in urothelial cancer

por Börcsök, Judit, Sztupinszki, Zsofia, Bekele, Raie, Gao, Sizhi P., Diossy, Miklos, Samant, Amruta S., Dillon, Kasia M., Tisza, Viktoria, Spisák, Sándor, Rusz, Orsolya, Csabai, Istvan, Pappot, Helle, Frazier, Zoë J., Konieczkowski, David J., Liu, David, Vasani, Naresh, Rodrigues, James A., Solit, David B., Hoffman-Censits, Jean H., Plimack, Elizabeth R., Rosenberg, Jonathan E., Lazaro, Jean-Bernard, Taplin, Mary-Ellen, Iyer, Gopa, Brunak, Søren, Lozsa, Rita, Van Allen, Eliezer M., Szüts, Dávid, Mouw, Kent W., Szallasi, Zoltan
Publicado en Clin Cancer Res (2020)

Frequent somatic CDH1 loss-of-function mutations in plasmacytoid-variant bladder cancer

por Al-Ahmadie, Hikmat A., Iyer, Gopa, Lee, Byron H., Scott, Sasinya N., Mehra, Rohit, Bagrodia, Aditya, Jordan, Emmet J., Gao, Sizhi Paul, Ramirez, Ricardo, Cha, Eugene K., Desai, Neil B., Zabor, Emily C., Ostrovnaya, Irina, Gopalan, Anuradha, Chen, Ying-Bei, Fine, Samson W., Tickoo, Satish K., Gandhi, Anupama, Hreiki, Joseph, Viale, Agnès, Arcila, Maria E., Dalbagni, Guido, Rosenberg, Jonathan E., Bochner, Bernard H., Bajorin, Dean F., Berger, Michael F., Reuter, Victor E., Taylor, Barry S., Solit, David B.
Publicado en Nat Genet (2016)

Genetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors

por Bagrodia, Aditya, Lee, Byron H., Lee, William, Cha, Eugene K., Sfakianos, John P., Iyer, Gopa, Pietzak, Eugene J., Gao, Sizhi Paul, Zabor, Emily C., Ostrovnaya, Irina, Kaffenberger, Samuel D., Syed, Aijazuddin, Arcila, Maria E., Chaganti, Raju S., Kundra, Ritika, Eng, Jana, Hreiki, Joseph, Vacic, Vladimir, Arora, Kanika, Oschwald, Dayna M., Berger, Michael F., Bajorin, Dean F., Bains, Manjit S., Schultz, Nikolaus, Reuter, Victor E., Sheinfeld, Joel, Bosl, George J., Al-Ahmadie, Hikmat A., Solit, David B., Feldman, Darren R.
Publicado en J Clin Oncol (2016)

Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts

por Kim, Kwanghee, Hu, Wenhuo, Audenet, François, Almassi, Nima, Hanrahan, Aphrothiti J., Murray, Katie, Bagrodia, Aditya, Wong, Nathan, Clinton, Timothy N., Dason, Shawn, Mohan, Vishnu, Jebiwott, Sylvia, Nagar, Karan, Gao, Jianjiong, Penson, Alex, Hughes, Chris, Gordon, Benjamin, Chen, Ziyu, Dong, Yiyu, Watson, Philip A., Alvim, Ricardo, Elzein, Arijh, Gao, Sizhi P., Cocco, Emiliano, Santin, Alessandro D., Ostrovnaya, Irina, Hsieh, James J., Sagi, Irit, Pietzak, Eugene J., Hakimi, A. Ari, Rosenberg, Jonathan E., Iyer, Gopa, Vargas, Herbert A., Scaltriti, Maurizio, Al-Ahmadie, Hikmat, Solit, David B., Coleman, Jonathan A.
Publicado en Nat Commun (2020)