Identification of a synthetic lethal relationship between nucleotide excision repair (NER) deficiency and irofulven sensitivity in urothelial cancer

PURPOSE: Cisplatin-based chemotherapy is a first-line treatment for muscle-invasive and metastatic urothelial cancer. Approximately 10% of bladder urothelial tumors have a somatic missense mutation in the nucleotide excision repair (NER) gene, ERCC2, which confers increased sensitivity to cisplatin-...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Börcsök, Judit, Sztupinszki, Zsofia, Bekele, Raie, Gao, Sizhi P., Diossy, Miklos, Samant, Amruta S., Dillon, Kasia M., Tisza, Viktoria, Spisák, Sándor, Rusz, Orsolya, Csabai, Istvan, Pappot, Helle, Frazier, Zoë J., Konieczkowski, David J., Liu, David, Vasani, Naresh, Rodrigues, James A., Solit, David B., Hoffman-Censits, Jean H., Plimack, Elizabeth R., Rosenberg, Jonathan E., Lazaro, Jean-Bernard, Taplin, Mary-Ellen, Iyer, Gopa, Brunak, Søren, Lozsa, Rita, Van Allen, Eliezer M., Szüts, Dávid, Mouw, Kent W., Szallasi, Zoltan
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026514/
https://ncbi.nlm.nih.gov/pubmed/33208343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-3316
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