Identification of a synthetic lethal relationship between nucleotide excision repair (NER) deficiency and irofulven sensitivity in urothelial cancer

PURPOSE: Cisplatin-based chemotherapy is a first-line treatment for muscle-invasive and metastatic urothelial cancer. Approximately 10% of bladder urothelial tumors have a somatic missense mutation in the nucleotide excision repair (NER) gene, ERCC2, which confers increased sensitivity to cisplatin-...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Börcsök, Judit, Sztupinszki, Zsofia, Bekele, Raie, Gao, Sizhi P., Diossy, Miklos, Samant, Amruta S., Dillon, Kasia M., Tisza, Viktoria, Spisák, Sándor, Rusz, Orsolya, Csabai, Istvan, Pappot, Helle, Frazier, Zoë J., Konieczkowski, David J., Liu, David, Vasani, Naresh, Rodrigues, James A., Solit, David B., Hoffman-Censits, Jean H., Plimack, Elizabeth R., Rosenberg, Jonathan E., Lazaro, Jean-Bernard, Taplin, Mary-Ellen, Iyer, Gopa, Brunak, Søren, Lozsa, Rita, Van Allen, Eliezer M., Szüts, Dávid, Mouw, Kent W., Szallasi, Zoltan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026514/
https://ncbi.nlm.nih.gov/pubmed/33208343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-3316
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