Polymerase theta expression is correlated with proliferative capacity but not with DNA repair deficiency status in solid tumors
Abstract Polymerase theta (POLθ) inhibitors were developed to overcome resistance to PARP inhibitor treatment in homologous recombination (HR) deficient cancer. Biomarkers identifying PARP inhibitor-resistant cancer cases that specifically rely on POLθ activity for cancer cell survival will help to...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Portfolio
2025-06-01
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| Collection: | npj Precision Oncology |
| Accès en ligne: | https://doi.org/10.1038/s41698-025-01000-w |
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