Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

Persistently activated or tyrosine-phosphorylated STAT3 (pSTAT3) is found in 50% of lung adenocarcinomas. pSTAT3 is found in primary adenocarcinomas and cell lines harboring somatic-activating mutations in the tyrosine kinase domain of EGFR. Treatment of cell lines with either an EGFR inhibitor or a...

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Detalhes bibliográficos
Main Authors: Gao, Sizhi Paul, Mark, Kevin G., Leslie, Kenneth, Pao, William, Motoi, Noriko, Gerald, William L., Travis, William D., Bornmann, William, Veach, Darren, Clarkson, Bayard, Bromberg, Jacqueline F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2096430/
https://ncbi.nlm.nih.gov/pubmed/18060032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31871
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