Emerging Mechanisms of Resistance to Androgen Receptor Inhibitors in Prostate Cancer

di Watson, Philip A., Arora, Vivek K., Sawyers, Charles L.
Pubblicato in Nat Rev Cancer (2015)

Androgen Receptor Signaling in Salivary Gland Cancer

di Dalin, Martin G., Watson, Philip A., Ho, Alan L., Morris, Luc G. T.
Pubblicato in Cancers (Basel) (2017)

Epidermal Growth Factor Receptor vIII Expression in U87 Glioblastoma Cells Alters Their Proteasome Composition, Function, and Response to Irradiation

di Kim, Kwanghee, Brush, James M., Watson, Philip A., Cacalano, Nicholas A., Iwamoto, Keisuke S., McBride, William H.
Pubblicazione 2008

Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

di Watson, Philip A., Chen, Yinan F., Balbas, Minna D., Wongvipat, John, Socci, Nicholas D., Viale, Agnes, Kim, Kwanghee, Sawyers, Charles L.
Pubblicazione 2010

GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance

di Lee, Eugine, Wongvipat, John, Choi, Danielle, Wang, Ping, Lee, Young Sun, Zheng, Deyou, Watson, Philip A, Gopalan, Anuradha, Sawyers, Charles L
Pubblicato in eLife (2019)

Annotating STEAP1 Regulation in Prostate Cancer with (89)Zr Immuno-PET

di Doran, Michael G., Watson, Philip A., Cheal, Sarah M., Spratt, Daniel E., Wongvipat, John, Steckler, Jeffrey M., Carrasquillo, Jorge A., Evans, Michael J., Lewis, Jason S.
Pubblicato in J Nucl Med (2014)

Overcoming mutation-based resistance to antiandrogens with rational drug design

di Balbas, Minna D, Evans, Michael J, Hosfield, David J, Wongvipat, John, Arora, Vivek K, Watson, Philip A, Chen, Yu, Greene, Geoffrey L, Shen, Yang, Sawyers, Charles L
Pubblicazione 2013

Androgen Deprivation Therapy Potentiates the Efficacy of Vascular Targeted Photodynamic Therapy of Prostate Cancer Xenografts

di Kim, Kwanghee, Watson, Philip A, Lebdai, Souhil, Jebiwott, Sylvia, Somma, Alexander J, La Rosa, Stephen, Mehta, Dipti, Murray, Katie S, Lilja, Hans, Ulmert, David, Monette, Sebastien, Scherz, Avigdor, Coleman, Jonathan A
Pubblicato in Clin Cancer Res (2018)

Harnessing Androgen Receptor Pathway Activation for Targeted Alpha Particle Radioimmunotherapy of Breast Cancer

di Thorek, Daniel L.J., Ku, Anson T., Mitsiades, Nicholas, Veach, Darren, Watson, Philip A., Metha, Dipti, Strand, Sven-Erik, Sharma, Sai Kiran, Lewis, Jason S., Abou, Diane S., Lilja, Hans G., Larson, Steven M., McDevitt, Michael R., Ulmert, David
Pubblicato in Clin Cancer Res (2018)

FOXA1 mutations alter pioneering activity, differentiation, and prostate cancer phenotypes

di Adams, Elizabeth J., Karthaus, Wouter R., Hoover, Elizabeth, Liu, Deli, Gruet, Antoine, Zhang, Zeda, Cho, Hyunwoo, DiLoreto, Rose, Chhangawala, Sagar, Liu, Yang, Watson, Philip A., Davicioni, Elai, Sboner, Andrea, Barbieri, Christopher E., Bose, Rohit, Leslie, Christina S., Sawyers, Charles L.
Pubblicato in Nature (2019)

Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer

di Tran, Chris, Ouk, Samedy, Clegg, Nicola J., Chen, Yu, Watson, Philip A., Arora, Vivek, Wongvipat, John, Smith-Jones, Peter M., Yoo, Dongwon, Kwon, Andrew, Wasielewska, Teresa, Welsbie, Derek, Chen, Charlie, Higano, Celestia S., Beer, Tomasz M., Hung, David T., Scher, Howard I., Jung, Michael, Sawyers, Charles L.
Pubblicazione 2009

Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer

di McDevitt, Michael R., Thorek, Daniel L. J., Hashimoto, Takeshi, Gondo, Tatsuo, Veach, Darren R., Sharma, Sai Kiran, Kalidindi, Teja Muralidhar, Abou, Diane S., Watson, Philip A., Beattie, Bradley J., Timmermand, Oskar Vilhemsson, Strand, Sven-Erik, Lewis, Jason S., Scardino, Peter T., Scher, Howard I., Lilja, Hans, Larson, Steven M., Ulmert, David
Pubblicato in Nat Commun (2018)

SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer

di Mu, Ping, Zhang, Zeda, Benelli, Matteo, Karthaus, Wouter R., Hoover, Elizabeth, Chen, Chi-Chao, Wongvipat, John, Ku, Sheng-Yu, Gao, Dong, Cao, Zhen, Shah, Neel, Adams, Elizabeth J., Abida, Wassim, Watson, Philip A., Prandi, Davide, Huang, Chun-Hao, de Stanchina, Elisa, Lowe, Scott W., Ellis, Leigh, Beltran, Himisha, Rubin, Mark A., Goodrich, David W., Demichelis, Francesca, Sawyers, Charles L.
Pubblicato in Science (2017)

Androgen receptor signaling regulates DNA repair in prostate cancers

di Polkinghorn, William R., Parker, Joel S., Lee, Man X., Kass, Elizabeth M., Spratt, Daniel E., Iaquinta, Phillip J., Arora, Vivek K., Yen, Wei-Feng, Cai, Ling, Zheng, Deyou, Carver, Brett S., Chen, Yu, Watson, Philip A., Shah, Neel P., Fujisawa, Sho, Goglia, Alexander G., Gopalan, Anuradha, Hieronymus, Haley, Wongvipat, John, Scardino, Peter T., Zelefsky, Michael J., Jasin, Maria, Chaudhuri, Jayanta, Powell, Simon N., Sawyers, Charles L.
Pubblicazione 2013

Internalization of secreted antigen–targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis

di Thorek, Daniel L. J., Watson, Philip A., Lee, Sang-Gyu, Ku, Anson T., Bournazos, Stylianos, Braun, Katharina, Kim, Kwanghee, Sjöström, Kjell, Doran, Michael G., Lamminmäki, Urpo, Santos, Elmer, Veach, Darren, Turkekul, Mesruh, Casey, Emily, Lewis, Jason S., Abou, Diane S., van Voss, Marise R. H., Scardino, Peter T., Strand, Sven-Erik, Alpaugh, Mary L., Scher, Howard I., Lilja, Hans, Larson, Steven M., Ulmert, David
Pubblicato in Sci Transl Med (2016)

Somatic tissue engineering in mouse models reveals an actionable role for WNT pathway alterations in prostate cancer metastasis

di Leibold, Josef, Ruscetti, Marcus, Cao, Zhen, Ho, Yu-Jui, Baslan, Timour, Zou, Min, Abida, Wassim, Feucht, Judith, Han, Teng, Barriga, Francisco M., Tsanov, Kaloyan M., Zamechek, Leah, Kulick, Amanda, Amor, Corina, Tian, Sha, Rybczyk, Katarzyna, Salgado, Nelson R., Sánchez-Rivera, Francisco J., Watson, Philip A., de Stanchina, Elisa, Wilkinson, John E., Dow, Lukas E., Abate-Shen, Cory, Sawyers, Charles L., Lowe, Scott W.
Pubblicato in Cancer Discov (2020)

Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer

di Zhang, Zeda, Karthaus, Wouter R., Lee, Young Sun, Gao, Vianne R., Wu, Chao, Russo, Joshua W., Liu, Menghan, Mota, Jose Mauricio, Abida, Wassim, Linton, Eliot, Lee, Eugine, Barnes, Spencer D., Chen, Hsuan-An, Mao, Ninghui, Wongvipat, John, Choi, Danielle, Chen, Xiaoping, Zhao, Huiyong, Manova-Todorova, Katia, de Stanchina, Elisa, Taplin, Mary-Ellen, Balk, Steven P., Rathkopf, Dana E., Gopalan, Anuradha, Carver, Brett S., Mu, Ping, Jiang, Xuejun, Watson, Philip A., Sawyers, Charles L.
Pubblicato in Cancer Cell (2020)

Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts

di Kim, Kwanghee, Hu, Wenhuo, Audenet, François, Almassi, Nima, Hanrahan, Aphrothiti J., Murray, Katie, Bagrodia, Aditya, Wong, Nathan, Clinton, Timothy N., Dason, Shawn, Mohan, Vishnu, Jebiwott, Sylvia, Nagar, Karan, Gao, Jianjiong, Penson, Alex, Hughes, Chris, Gordon, Benjamin, Chen, Ziyu, Dong, Yiyu, Watson, Philip A., Alvim, Ricardo, Elzein, Arijh, Gao, Sizhi P., Cocco, Emiliano, Santin, Alessandro D., Ostrovnaya, Irina, Hsieh, James J., Sagi, Irit, Pietzak, Eugene J., Hakimi, A. Ari, Rosenberg, Jonathan E., Iyer, Gopa, Vargas, Herbert A., Scaltriti, Maurizio, Al-Ahmadie, Hikmat, Solit, David B., Coleman, Jonathan A.
Pubblicato in Nat Commun (2020)