Androgen receptor signaling regulates DNA repair in prostate cancers

We demonstrate that the androgen receptor (AR) regulates a transcriptional program of DNA repair genes that promotes prostate cancer radioresistance, providing a potential mechanism by which androgen deprivation therapy (ADT) synergizes with ionizing radiation (IR). Using a model of castration-resis...

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Detalhes bibliográficos
Main Authors: Polkinghorn, William R., Parker, Joel S., Lee, Man X., Kass, Elizabeth M., Spratt, Daniel E., Iaquinta, Phillip J., Arora, Vivek K., Yen, Wei-Feng, Cai, Ling, Zheng, Deyou, Carver, Brett S., Chen, Yu, Watson, Philip A., Shah, Neel P., Fujisawa, Sho, Goglia, Alexander G., Gopalan, Anuradha, Hieronymus, Haley, Wongvipat, John, Scardino, Peter T., Zelefsky, Michael J., Jasin, Maria, Chaudhuri, Jayanta, Powell, Simon N., Sawyers, Charles L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888815/
https://ncbi.nlm.nih.gov/pubmed/24027196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0172
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