Glucocorticoid Receptor Confers Resistance to Anti-Androgens by Bypassing Androgen Receptor Blockade

The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Here we identify induction of glucocorticoid receptor (GR) expression as a common feature of drug resistant tumors in a credentialed preclinical model, a finding also confirmed in pat...

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Detalhes bibliográficos
Main Authors: Arora, Vivek K., Schenkein, Emily, Murali, Rajmohan, Subudhi, Sumit K., Wongvipat, John, Balbas, Minna D., Shah, Neel, Cai, Ling, Efstathiou, Eleni, Logothetis, Chris, Zheng, Deyou, Sawyers, Charles L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932525/
https://ncbi.nlm.nih.gov/pubmed/24315100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.11.012
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