Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer

In prostate cancer, resistance to the antiandrogen enzalutamide (Enz) can occur through bypass of androgen receptor (AR) blockade by the glucocorticoid receptor (GR). In contrast to fixed genomic alterations, here we show that GR-mediated antiandrogen resistance is adaptive and reversible due to reg...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Shah, Neel, Wang, Ping, Wongvipat, John, Karthaus, Wouter R, Abida, Wassim, Armenia, Joshua, Rockowitz, Shira, Drier, Yotam, Bernstein, Bradley E, Long, Henry W, Freedman, Matthew L, Arora, Vivek K, Zheng, Deyou, Sawyers, Charles L
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593504/
https://ncbi.nlm.nih.gov/pubmed/28891793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27861
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