Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer

In prostate cancer, resistance to the antiandrogen enzalutamide (Enz) can occur through bypass of androgen receptor (AR) blockade by the glucocorticoid receptor (GR). In contrast to fixed genomic alterations, here we show that GR-mediated antiandrogen resistance is adaptive and reversible due to reg...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Shah, Neel, Wang, Ping, Wongvipat, John, Karthaus, Wouter R, Abida, Wassim, Armenia, Joshua, Rockowitz, Shira, Drier, Yotam, Bernstein, Bradley E, Long, Henry W, Freedman, Matthew L, Arora, Vivek K, Zheng, Deyou, Sawyers, Charles L
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2017
Sujets:
Cancer Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593504/
https://ncbi.nlm.nih.gov/pubmed/28891793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27861
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires