SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer

Some cancers evade targeted therapies through a mechanism known as lineage plasticity, whereby tumor cells acquire phenotypic characteristics of a cell lineage whose survival no longer depends on the drug target. We use in vitro and in vivo human prostate cancer models to show that these tumors can...

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Veröffentlicht in:Science
Hauptverfasser: Mu, Ping, Zhang, Zeda, Benelli, Matteo, Karthaus, Wouter R., Hoover, Elizabeth, Chen, Chi-Chao, Wongvipat, John, Ku, Sheng-Yu, Gao, Dong, Cao, Zhen, Shah, Neel, Adams, Elizabeth J., Abida, Wassim, Watson, Philip A., Prandi, Davide, Huang, Chun-Hao, de Stanchina, Elisa, Lowe, Scott W., Ellis, Leigh, Beltran, Himisha, Rubin, Mark A., Goodrich, David W., Demichelis, Francesca, Sawyers, Charles L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247742/
https://ncbi.nlm.nih.gov/pubmed/28059768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah4307
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