Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer

Despite the development of second-generation antiandrogens, acquired resistance to hormone therapy remains a major challenge in treating advanced prostate cancer. We find that cancer-associated fibroblasts (CAFs) can promote antiandrogen resistance in mouse models and in prostate organoid cultures....

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Publicat a:Cancer Cell
Autors principals: Zhang, Zeda, Karthaus, Wouter R., Lee, Young Sun, Gao, Vianne R., Wu, Chao, Russo, Joshua W., Liu, Menghan, Mota, Jose Mauricio, Abida, Wassim, Linton, Eliot, Lee, Eugine, Barnes, Spencer D., Chen, Hsuan-An, Mao, Ninghui, Wongvipat, John, Choi, Danielle, Chen, Xiaoping, Zhao, Huiyong, Manova-Todorova, Katia, de Stanchina, Elisa, Taplin, Mary-Ellen, Balk, Steven P., Rathkopf, Dana E., Gopalan, Anuradha, Carver, Brett S., Mu, Ping, Jiang, Xuejun, Watson, Philip A., Sawyers, Charles L.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7472556/
https://ncbi.nlm.nih.gov/pubmed/32679108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.06.005
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