Glucocorticoid Receptor Confers Resistance to Anti-Androgens by Bypassing Androgen Receptor Blockade

The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Here we identify induction of glucocorticoid receptor (GR) expression as a common feature of drug resistant tumors in a credentialed preclinical model, a finding also confirmed in pat...

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Bibliografiske detaljer
Main Authors: Arora, Vivek K., Schenkein, Emily, Murali, Rajmohan, Subudhi, Sumit K., Wongvipat, John, Balbas, Minna D., Shah, Neel, Cai, Ling, Efstathiou, Eleni, Logothetis, Chris, Zheng, Deyou, Sawyers, Charles L.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932525/
https://ncbi.nlm.nih.gov/pubmed/24315100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.11.012
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