Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer

SUMMARY: Prostate cancer is characterized by its dependence on androgen receptor and frequent activation of PI3K signaling. We find that AR transcriptional output is decreased in human and murine tumors with PTEN deletion and that PI3K pathway inhibition activates AR signaling by relieving feedback...

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Autori principali: Carver, Brett S, Chapinski, Caren, Wongvipat, John, Hieronymus, Haley, Chen, Yu, Chandarlapaty, Sarat, Arora, Vivek K, Le, Carl, Koutcher, Jason, Scher, Howard, Scardino, Peter T, Rosen, Neal, Sawyers, Charles L
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142785/
https://ncbi.nlm.nih.gov/pubmed/21575859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.04.008
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