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PTEN is a protein tyrosine phosphatase for IRS1
The biological function of the PTEN tumor suppressor is mainly attributed to its lipid phosphatase activity. This study demonstrates that mammalian PTEN is a protein tyrosine phosphatase that selectively dephosphorylates insulin receptor substrate-1 (IRS1), a mediator of insulin and IGF signals. IGF...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4167033/ https://ncbi.nlm.nih.gov/pubmed/24814346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2828 |
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