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PTEN is a protein tyrosine phosphatase for IRS1

The biological function of the PTEN tumor suppressor is mainly attributed to its lipid phosphatase activity. This study demonstrates that mammalian PTEN is a protein tyrosine phosphatase that selectively dephosphorylates insulin receptor substrate-1 (IRS1), a mediator of insulin and IGF signals. IGF...

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Detalles Bibliográficos
Main Authors: Shi, Yuji, Wang, Junru, Chandarlapaty, Sarat, Cross, Justin, Thompson, Craig, Rosen, Neal, Jiang, Xuejun
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167033/
https://ncbi.nlm.nih.gov/pubmed/24814346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2828
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