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ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss
Studies of ETS-mediated prostate oncogenesis have been hampered by the lack of suitable experimental systems. Here we describe a new conditional mouse model which gives robust, homogenous ERG expression throughout the prostate. When combined with homozygous Pten loss, mice developed accelerated, hig...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3737318/ https://ncbi.nlm.nih.gov/pubmed/23817021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3216 |
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