ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss

Studies of ETS-mediated prostate oncogenesis have been hampered by the lack of suitable experimental systems. Here we describe a new conditional mouse model which gives robust, homogenous ERG expression throughout the prostate. When combined with homozygous Pten loss, mice developed accelerated, hig...

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Библиографические подробности
Главные авторы: Chen, Yu, Chi, Ping, Rockowitz, Shira, Iaquinta, Phillip J., Shamu, Tambudzai, Shukla, Shipra, Gao, Dong, Sirota, Inna, Carver, Brett S., Wongvipat, John, Scher, Howard I., Zheng, Deyou, Sawyers, Charles L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737318/
https://ncbi.nlm.nih.gov/pubmed/23817021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3216
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