Internalization of secreted antigen–targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis

Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targe...

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Publicado no:Sci Transl Med
Main Authors: Thorek, Daniel L. J., Watson, Philip A., Lee, Sang-Gyu, Ku, Anson T., Bournazos, Stylianos, Braun, Katharina, Kim, Kwanghee, Sjöström, Kjell, Doran, Michael G., Lamminmäki, Urpo, Santos, Elmer, Veach, Darren, Turkekul, Mesruh, Casey, Emily, Lewis, Jason S., Abou, Diane S., van Voss, Marise R. H., Scardino, Peter T., Strand, Sven-Erik, Alpaugh, Mary L., Scher, Howard I., Lilja, Hans, Larson, Steven M., Ulmert, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568040/
https://ncbi.nlm.nih.gov/pubmed/27903863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf2335
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