Internalization of secreted antigen–targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis

Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targe...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Sci Transl Med
Main Authors: Thorek, Daniel L. J., Watson, Philip A., Lee, Sang-Gyu, Ku, Anson T., Bournazos, Stylianos, Braun, Katharina, Kim, Kwanghee, Sjöström, Kjell, Doran, Michael G., Lamminmäki, Urpo, Santos, Elmer, Veach, Darren, Turkekul, Mesruh, Casey, Emily, Lewis, Jason S., Abou, Diane S., van Voss, Marise R. H., Scardino, Peter T., Strand, Sven-Erik, Alpaugh, Mary L., Scher, Howard I., Lilja, Hans, Larson, Steven M., Ulmert, David
Formato: Artigo
Idioma:Inglês
Publicado: 2016
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568040/
https://ncbi.nlm.nih.gov/pubmed/27903863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf2335
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares