Internalization of secreted antigen–targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis

Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targe...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Thorek, Daniel L. J., Watson, Philip A., Lee, Sang-Gyu, Ku, Anson T., Bournazos, Stylianos, Braun, Katharina, Kim, Kwanghee, Sjöström, Kjell, Doran, Michael G., Lamminmäki, Urpo, Santos, Elmer, Veach, Darren, Turkekul, Mesruh, Casey, Emily, Lewis, Jason S., Abou, Diane S., van Voss, Marise R. H., Scardino, Peter T., Strand, Sven-Erik, Alpaugh, Mary L., Scher, Howard I., Lilja, Hans, Larson, Steven M., Ulmert, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568040/
https://ncbi.nlm.nih.gov/pubmed/27903863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf2335
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